The Cyclones scored 24 unanswered points in the second half for the win.
Kendall walked off the field without being able to lift his right arm with an apparent shoulder injury. Jack Allison came in to play quarterback for the Mountaineers. West Virginia kept even with the Cyclones until halftime before Iowa State began pulling away in the fourth quarter.
Follow MetroNews for postgame coverage. Iowa State 31, West Virginia 14 The Cyclones faced minimal resistance on a seven-play, yard drive to put the game out of reach.
Brock Purdy hit Joe Scates for an yard touchdown that put the nail in the coffin. The Cyclones converted two third downs on the drive, and neither was a short one.
Third Quarter Iowa State 21, West Virginia 14 West Virginia will have to find a way to win without either of its starting cornerbacks. Simmons for a 9-yard touchdown right before halftime. It was a masterful drive for the backup quarterback, who went 6 of 7 for 77 yards. The West Virginia defense should have been off the field after stopping Iowa State on third-and, but an illegal hands to the face penalty on linebacker VanDarius Cowan kept the Mountaineers on the field.
Purdy finished the drive with a 2-yard touchdown run. The Cyclones converted a fourth down and third down on the scoring drive, with both coming on completions to big tight end Charlie Kolar.
The Mountaineers will need to find a way to limit Kolar the rest of the way, if possible. First Quarter West Virginia 7, Iowa State 0 Freshman safety Tykee Smith scored his first college touchdown on a stunning yard interception return for a touchdown.
Iowa State running back Kene Nwagwu bobbled a pass, which was then bobbled by Smith before he reached up to corral it and then made his way into the end zone. Pregame Iowa State will be without its top defensive player, safety Greg Eisworth.
Greg Eisworth isn't going through warmups. Looks like he won't be a go today.
Eisworth leads the Cyclones with 39 tackles. Iowa State is also without its top defensive lineman, end JaQuan Bailey. Pettaway is averaging 18 yards per game and has two touchdowns this season.
West Virginia is also without No. Banks, who has played sparingly this season. Wide receiver Sean Ryan, who was ruled out earlier this week, is being replaced in the lineup by Bryce Wheaton.